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J. People Plants Environ > Volume 22(1); 2019 > Article
Journal of People, Plants, and Environment 2019;22(1):39-52.
DOI: https://doi.org/10.11628/ksppe.2019.22.1.039    Published online February 28, 2019.
Inhibitory Effects of Collagen Coated Coffee Bean Intake on Skin Aging
In-Ah Lee1  , Mi-Ae Ha2, Yong-Wook Shin2,3 
1Department of Chemistry, College of Natural Science, Kunsan National University, Gunsan 54150, Korea
2Department of Agronomy & Medicinal Plant Resources, Gyeongnam National University of Science and Technology, Jinju 52725, Korea
3International Garden Institute, Gyeongnam National University of Science and Technology, Jinju 52725, Korea
Correspondence:  Yong-Wook Shin,
Email: ywsynn@gntech.ac.kr
To evaluate the protective effect of collagen peptide-coated coffee extract on skin aging, cell viability was measured with a MTT assay using cultured CCD-986sk fibroblasts, and its effect on wrinkles in the skin of hairless mice induced by UVB-irradiation was examined. In addition, its effect on procollagen synthesis and anti-oxidative, and its inhibitory activity against collagenase, elastase, tyrosinase and MMP-1 were analysed. After the 30-minute topical treatment, the animals were exposed to UVB irradiation (60-100 mJ/cm2) for 4 weeks and its intensity increased during the period. Under the experimental conditions set in this study, the skin thickness of hairless mice significantly decreased (11.8-21.3%) compared to the control group. Based on these results, the prolonged oral intake of a collagen peptide mixture with coffee is expected to significantly increase the synthesis of procollagen in dermal fibroblasts, thereby contributing to the alleviation of wrinkling and lowered elasticity due to structural damage to the dermal layer caused by UV. The oral intake of collagen-coated coffee contributes to increasing collagen biosynthesis in a dose-dependent manner and alleviates the symptoms of thickened keratin caused by UV irradiation. However, it did not inhibit the enzymes involved in skin aging, whitening, wrinkle improvement, and antioxidation. Based on the these results, it can be concluded that the intake of collagen peptide-coated coffee extract can be utilized as an alternative material for the prevention or treatment of diseases associated with photoaging.
KeyWords: coffee bean, collagen peptide, collagen synthesis, photo-aging
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